Measles Virus, a Weapon Against Cancer

This magic world is still more than 10 million infections and measles, measles, measles vaccine is developed that can help eliminate the causes 150,000 deaths is due in part. But he also has another source: scientists, "Re-targeted" attack only cancer cells and, therefore, believe that the new change in measles virus, and a powerful cancer treatment.
Measles virus transformation of cells into a weapon against cancer one step closer to reality Now a new discovery process have been dreaming about. Rochester, Minnesota and the Mayo Clinic in Galveston University of Texas Medical Branch, a group of researchers, including scientists, to connect and measles virus infected cells gave detailed information used by the complex molecular mechanism.
Measles virus genetic material in a spherical shell around the main actors in the form of two proteins. Receptor molecules on the cell's outer membrane is connected to a host of vegetable proteins and viruses to infect cells, the cell membrane and fusion of viral envelope protein binding to another. Study published in the current issue of Nature Structural Biology and Molecular Biology, the flexibility inherent in a cell fusion protein binding showed that the pre-condition for the start of the process.
"The attack our Mayo Clinic employees, Roberto Cattaneo, a certain cancer cells, measles virus, routing, and for the general purpose as possible, both he and his team like to know about the mechanisms of measles virus infection, no," said UTMB professor Werner Braun author of the study. "We have to help them better target their experimental studies and our theoretical predictions with numerical methods, have long-term cooperation with your own group."
UTMB Health Research Numan Oezguer use computer models to predict the molecular interaction sites of protein attachment to the head of mobility and interaction, and change the suggested specific mutation. Cattaneo led - - Mayo Clinic group, the results of these experiments, the cell entry of the rotational movement of the measles virus is connected to the heads showed protein binding.
Mayo Clinic to get an accurate picture of the mechanism of a dynamic group of measles virus mutation, head-binding protein mobility, and then the mutant virus to infect cells in the test to determine the possibility of any kind created. "Dr. Cattaneo experiments burying two parts of protein were found to have an enormous impact on the movement of infectious diseases do," said Brown. "Simply put, we believe that as a lever - this kind of movement in order to produce the cell attachment protein receptors for the right move, and the fusion protein causes and leads to infectivity."
Other authors of paper Cattaneo, Chanakha Navaratnarajah, Levi Rupp, Lee Kai and the Mayo Clinic has Leonard Vincent. Mayo Clinic Cancer Center and the National Institutes of Health supported this research.